Molecular Basis of Cardiovascular Disease
This inherently multidisciplinary research field is designed to provide our trainees with the knowledge base, technical abilities, problem solving skills and research experience necessary to find bold new approaches to aid understanding, diagnosis and treatment of heart disease. Areas of research interest in this program include regulation of cardiac growth, regulation of cardiovascular function and metabolism, regulation of muscle contraction and protein turnover, and signal transduction pathways and transcriptional regulation in healthy and diseased myocardium.
Numerous model systems are used by our faculty, including molecular and whole organ physiological approaches focused on transgenic and knock out animal models, surgical models of cardiovascular disease, as well as state-of-the-art analyses of isolated adult cardiac myocytes in vitro. These exciting studies are leading to the identification of novel therapeutic targets for the treatment of cardiovascular disease.
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| Kelley
Argraves, Ph.D. |
Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis |
| John
M. Arthur, M.D., Ph.D. |
Discovery of Disease Biomarkers Using Proteomic and Informatic Technologies |
| Craig
Beeson, Ph.D. |
Regulation of Cardiac Bioenergetics during Stress Responses |
| Amy
Bradshaw, Ph.D. |
Collagen Deposition in Cardiac Hypertrophy |
| Julie
Chao, Ph.D. |
Roles of the Tissue Kallikrein-Kinin System in Cardiovascular Disease |
| George
Cooper, IV, M.D. |
Structure-Function Relationships of the Cardiac Extramyofilament Cytoskeleton |
| Brent
M. Egan, M.D. |
Obesity, Oxidative Stress and Cardiovascular Risk |
| Carol
Eisenberg, Ph.D. |
Phenotypic Potential of Adult Tissue-derived Stem Cells |
| Leonard
Eisenberg, Ph.D. |
Regulation of Stem Cell Potential and Cardiac Induction |
| Robert
G. Gourdie, Ph.D. |
Developmental and Molecular Biology of Cardiac Conduction Wound Healing |
| Samar
Hammad, Ph.D. |
Sphingolipid Signaling Response to Modified Low-density Lipoprotein-Immune Complexes in Human Macrophages |
| Brett
Harris, Ph.D. |
The Development of the Atrio-ventricular Conduction System |
| John
S. Ikonomidis, M.D., Ph.D. |
Extracellular Matrix Remodeling in Thoracic Aortic Aneurysm Disease |
| Ayad
A. Jaffa, Ph.D. |
Mechanisms of Diabetic Vascular and Renal Disease |
| Daniel
Knapp, Ph.D. |
Proteomic Analysis Using Mass Spectrometry Approaches |
| Edward
Krug, Ph.D. |
Assessing the Anatomical Proteome of Heart Morphogenesis |
| Steven
W. Kubalak, Ph.D. |
Signaling Mechanisms Regulating Cardiac Remodeling |
| Dhandapani
Kuppuswamy, Ph.D. |
Growth and Protection of Hypertrophing Myocardium |
| Amanda
LaRue, Ph.D. |
Hematopoietic Stem Cells in the Development and Progression of Solid Tumors |
| Kyo
Ho Lee, M.D., Ph.D. |
Transcriptional Regulation in Cardiac Development |
| Louis
Lutrell, M.D., Ph.D. |
G Protein-coupled Receptor Signaling in the Cardiovascular System |
| Roger
Markwald, Ph.D. |
Developmental Basis of Cardiovascular Disease |
| Paul
J. McDermott, Ph.D. |
Translational Regulation of Cardiac Protein Synthesis |
| Donald
R. Menick, Ph.D. |
Regulation of Gene Expression in Cardiac Myocytes |
| Suniti
Misra, Ph.D. |
Role of Hyaluronan in Intimal Thickening in Congenital Birth Defect and Atherosclerosis |
| Vladimir
Mironov, M.D., Ph.D. |
Cardiovascular Tissue Engineering and Cardiovascular Regenerative Medicine |
| Terrence
X. O'Brien, M.D. |
Transcriptional Regulation of Specified Genes Involved in Cardiac Hypertrophy and the Development of the Conduction System |
| Anand
Ramamurthi, Ph.D. |
Tissue-derived Biomaterials for Vascular and Cardiac Regeneration and Repair |
| Kevin
L. Schey, Ph.D. |
Proteomics and Protein Structure |
| Francis
G. Spinale, M.D., Ph.D. |
Cellular Mechanisms of Heart Failure |
| Robert
Thompson, Ph.D. |
Regulation of Myocyte Proliferation in Heart Development |
| Arno
Wessels, Ph.D. |
Mechanisms of Cardiac Morphogenesis |
| Michael
R. Zile, M.D. |
Diastolic Heart Failure and Growth Regulation |
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