Training to Improve Cardiovascular Drug Therapy
NIH Predoctoral and Postdoctoral Fellowships in Cardiovascular Science
Recent Publications

Balasubramanian S, Shiraishi H, Yamane K, Mani S, Wiley CD, Tuxworth WJ Jr, Copper G IV, and Kuppuswamy D. Enhanced ubiquitination of cytoskeletal proteins in pressure overloaded myocardium is accompanied by changes in specific E3 ligases. In revision.

Ervin LA, Ball LE, Crouch RK and Schey KL. Phosphorylation and glycosylation of bovine lens MP20. Invest Ophthalmol Vis Sci 46(2):627-35, 2005.

Hunter AW, Barker RJ, Zhu C, Gourdie RG. Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell. 16:5686-5698, 2005.

Zhu C, Barker RJ, Hunter AW, Zhang Y, Jourdan J and Gourdie RG. Quantitative analysis of ZO-1 co-localization with Cx43 gap junction plaques in cultures of rat neonatal cardiomyocytes. Microsc Microanal. 11:244-248, 2004. (Nominated for Paper of the Year by Molecular Biology of the Cell.)

Drake CJ, Fleming PA, LaRue AC, Barth JL, Chintalapudi MR and Argraves WS. Differential distribution of cubilin and megalin expression in the mouse embryo. Anatomical Record Part 277A:163-170, 2004.

LaRue AC, Zile MH and Drake CJ. Normal vascular morphogenesis requires retinol-mediated regulation of endothelial cell numbers. Developmental Dynamics 230(4):666-70, 2004.

Tuxworth WJ, Saghir AN, Spruill LS, Menick DR and McDermott PJ. Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: The consequence of secondary structure in the 5´-untranslated region of mRNA. Biochemical Journal 378(Pt 1):73-82, 2004.

Walgren JL, Amani Z, McMillan JM, Locher M and Buse MG. Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes. Metabolism 53(2):165-73, 2004.

Mukherjee R, Yarbrough WM, Reese ES, Leiser JS, Sample JA, Mingoia JT, Hardin AE, Stroud RE, McLean JE, Hendrick JW and Spinale FG. Myocyte contractility with caspase inhibition and simulated hyperkalemic cardioplegic arrest. Ann Thorac Surg 77(5):1684-90, 2004.

Yarbrough WM, Mukherjee R, Squires CE, Reese ES, Leiser JS, Stroud RE, Sample JA, Hendrick JW, Mingoia JT, McLean JE, Hardin AE, Dowdy KB and Spinale FG. Caspase inhibition attenuates contractile dysfunction following cardioplegic arrest and rewarming in the setting of left ventricular failure. J Cardiovasc Pharmacol 44(6):645-50, 2004.

Hamilton MH, Cook LA, McRackan TR, Schey KL and Hildebrandt JD. Gamma 2 subunit of G protein heterotrimer is an N-end rule ubiquitylation substrate. Proc Natl Acad Sci USA 100(9):5081-6, 2003.

Hunter AW, Jourdan J and Gourdie RG. Fusion of GFP to the carboxyl terminus of connexin43 increases gap junction size in HeLa cells. Cell Commun Adhes 10(4-6):211-214, 2003.

Johnson KR, Johnson KY, Becker KP, Bielawski J, Mao C and Obeid LM. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J Biol Chem 278(36):34541-7, 2003.

Ishikawa F, Drake CJ, Yang S, Fleming P, Minamiguchi H, Visconti RP, Crosby CV, Argraves WS, Harada M, Key LL Jr, Livingston AG, Wingard JR and Ogawa M. Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann N Y Acad Sci 2003 May;996:174-85, 2003.

Walgren JL, Vincent TS, Schey KL and Buse MG. High glucose and insulin promote O-GlcNAc modification of proteins, including alpha-tubulin. Am J Physiol Endocrinol Metab 284(2):E424-34, 2003.

Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Baskin JM, Deschamps AM, Lowry AS, Escobar GP, Lucas DG, Yarbrough WM, Zile MR and Spinale FG. Myocardial infarct expansion and matrix metalloproteinase inhibition. Circulation 107(4):618-25, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Hendrick JW, Sample JA, Dowdy KB, McLean JE, Mingoia JT, Crawford FA Jr and Spinale FG. Modulation of calcium transport improves myocardial contractility and enzyme profiles after prolonged ischemia-reperfusion. Ann Thorac Surg 76(6):2054-61, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Mingoia JT, Sample JA, Hendrick JW, Dowdy KB, McLean JE, Lowry AS, O'Neill TP and Spinale FG. Selective targeting and timing of matrix metalloproteinase inhibition in post-myocardial infarction remodeling. Circulation 108(14):1753-9, 2003.

Yarbrough WM, Mukherjee R, Brinsa TA, Dowdy KB, Scott AA, Escobar GP, Joffs C, Lucas DG, Crawford FA Jr and Spinale FG. Matrix metalloproteinase inhibition modifies left ventricular remodeling after myocardial infarction in pigs. J Thorac Cardiovasc Surg 125(3):602-10, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Mingoia JT, Sample JA, Hendrick JW, Dowdy KB, McLean JE, Stroud RE and Spinale FG. Direct inhibition of the sodium/hydrogen exchanger after prolonged regional ischemia improves contractility on reperfusion independent of myocardial viability. J Thorac Cardiovasc Surg 126(5):1489-97, 2003.

Yarbrough WM and Spinale FG. Large animal models of congestive heart failure: a critical step in translating basic observations into clinical applications. J Nucl Cardiol 10(1):77-86, 2003.

Yarbrough WM, Mukherjee R, Escobar GP, Sample JA, McLean JE, Dowdy KB, Hendrick JW, Gibson WC, Hardin AE, Mingoia JT, White PC, Stiko A, Armstrong RC, Crawford FA and Spinale FG. Pharmacologic inhibition of intracellular caspases after myocardial infarction attenuates left ventricular remodeling: a potentially novel pathway. J Thorac Cardiovasc Surg 126(6):1892-9, 2003.

Argraves KM, Obeid LM and Hannun YA. Sphingohpids in vascular biology. Proceedings for: eicosanoids and other bioactive lipids in cancer, inflammation and related diseases. Adv Exp Med Biol 507:439-44, 2002.

Cook LA, Wilcox MD, Dingus J, Schey KL and Hildebrandt JD. Separation and analysis of G protein gamma subunits. Methods Enzymol 344:209-33, 2002.

Schey KL, Busman M, Cook LA, Hamm H and Hildebrandt JD. Structural characterization of intact G protein gamma subunits by mass spectrometry. Methods Enzymol 344:586-97, 2002.

Johnson KR and Fan W. Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil. Anticancer Res 22(6A):3197-204, 2002.

Johnson KR, Becker KP, Facchinetti MM, Hannun YA and Obeid LM. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J Biol Chem 277(38):35257-62, 2002.

Hannun YA, Luberto C and Argraves KM. Enzymes of sphingohpid metabolism: from modular to integrative signaling. Biochemistry 40(16):4893-903, 2001.

Christopher J, Velarde V, Zhang D, Mayfield D, Mayfield R, and Jaffa AA. Regulation of B2-kinin receptors by high glucose in vascular smooth muscle cells. Am. J. Physiol. 280:Hl537-Hl 546, 2001.

Christopher JT, Mayfield RM and Jaffa AA. Induction of B(1)-kinin receptors in vascular smooth muscle cells: cellular mechanisms of map kinase activation. Hypertension 38(3 Pt 2):602-5, 2001.

Velarde V, Jenkins A, Christopher J, Joyce KC, Mayfield D, Lyons T, Mayfield R and Jaffa AA. Activation of MAPK activation by modified low-density lipoproteins in vascular smooth muscle cells. Journal of Applied Biology 91(3):1412-20, 2001.

Cook LA, Schey KL, Cleator JH, Wilcox MD, Dingus J and Hildebrandt JD. Identification of a region in G protein gamma subunits conserved among species variants but hypervariable among subunit isoforms. Protein Sci 10(12):2548-55, 2001.

Gunasinghe SK, Ikonomidis J and Spinale FG. Contributory role of matrix metalloproteinases in cardiovascular remodeling. Current Drug Targets-Cardiovascular and Haematological Disorders 1(2):75-91, 2001.

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