Cell Signaling
Cell regulation encompasses all the functions cells carry out to maintain homeostasis, in particular their responses to extracellular signals (hormones, neurotransmitters, etc.) and how cells transduce intracellular responses prompted by such signals. In addition to endogenous agents, many drugs and environmental agents use these same mechanisms to produce their most important effects. Understanding of cell signaling processes is fundamental to all areas of cardiovascular research. Numerous research opportunities exist within this program ranging from studies exploring new cell signaling mechanisms, to those examining aberrant signaling mechanisms associated with cardiovascular disease. Significantly, many of the recent breakthroughs in cardiovascular therapeutics result from basic studies on signaling molecules. |
|
| Kelley
Argraves, Ph.D. | Role of Sphingosine-1-Phosphate in Vasculogenesis and Angiogenesis |
| Scott
W. Argraves, Ph.D. |
Extracellular
Matrix Biology |
| John
Baatz, Ph.D. |
Characterization
of Hemoglobin and Surfactant Protein in Distal Airway Cells |
| Craig
Beeson, Ph.D. |
Regulation
of Cardiac Bioenergetics during Stress Responses |
| Maria
Buse, M.D., Ph.D. |
Diabetes:
Mechanisms of Insulin Resistance |
| Julie
Chao, Ph.D. |
Roles
of the Tissue Kallikrein-Kinin System in Cardiovascular Disease |
| James
A. Cook, Ph.D. |
Signal
Transduction Pathways in Shock |
| Samar
Hammad, Ph.D. |
Sphingolipid
Signaling Response to Modified Low-density Lipoprotein-Immune
Complexes in Human Macrophages |
| Yusuf
A. Hannun, M.D. |
Lipid mediated
signaling and biology |
| Brett
Harris, Ph.D. |
The
Development of the Atrio-ventricular Conduction System |
| Stanley
Hoffman, Ph.D. |
Extracellular
Matrix Patterning and Remodeling in Heart Development and Disease |
|
| Tien
Hsu, Ph.D. |
Signal Transduction
and Vascular Development in Drosophila |
| Ayad
A. Jaffa, Ph.D. |
Mechanisms
of Diabetic Vascular and Renal Disease |
| Steven
W. Kubalak, Ph.D. |
Signaling
Mechanisms Regulating Cardiac Remodeling |
| Dhandapani
Kuppuswamy, Ph.D. |
Growth
and Protection of Hypertrophing Myocardium |
| Kyo Ho
Lee, M.D., Ph.D. |
Transcriptional
Regulation in Cardiac Development |
| Louis
Lutrell, M.D., Ph.D. |
G Protein-coupled
Receptor Signaling in the Cardiovascular System |
| Paul
J. McDermott, Ph.D. |
Translational
Regulation of Cardiac Protein Synthesis |
| Donald
R. Menick, Ph.D. |
Regulation
of Gene Expression in Cardiac Myocytes |
| Suniti
Misra, Ph.D. |
Role of
Hyaluronan in Intimal Thickening in Congenital Birth Defect
and Atherosclerosis |
| Terrence
X. O'Brien, M.D. |
Transcriptional
Regulation of Specified Genes Involved in Cardiac Hypertrophy
and the Development of the Conduction System |
| Rick
Schnellmann, Ph.D. |
Elucidation
of Signaling Pathways of Cell Injury, Death and Regeneration |
| Steve
Tomlinson, Ph.D. |
The Complement
System and Vascular Inflammation |
| Bryan
Toole, Ph.D. |
Functions of
Hyaluronan and Emmprin in Oncogenic, Inflammatory and Atherosclerotic
Signaling Pathways |
| Maria
Trojanowska, Ph.D. |
Regulation
of ECM Remodeling |
|
