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Cardiac Stem Cells and Regenerative Medicine
 Regenerative medicine is an emerging field that intersects both basic science and clinical research. This research is focused on the regeneration and remodeling of tissue and organs for the purpose of repairing, replacing, maintaining, or enhancing cardiac function, as well as the engineering and growing functional tissue substitutes in vitro for implantation in vivo as a biological replacement for damaged or diseased myocardium. Areas of work in cardiac tissue engineering include cell seeding on solid biodegradable scaffolds, embedding and casting in 3D hydrogels, and technologies based on principles of tissue self-assembly (cell sheet technology, magnetic force-based tissue engineering). The studies use neonatal cardiomyocytes, as well as initiating the examination of the utility of stem cell lines as potential resources for regeneration of new myocytes for bioengineered cardiac tissue. Other studies include using mice with genetically labeled cells to trace bone marrow stem cell mobilization and recruitment into heart valve tissue. |
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| George
Cooper, IV, M.D. |
Structure-Function Relationships of the Cardiac Extramyofilament Cytoskeleton |
| Carol
A. Eisenberg, Ph.D. |
Phenotypic Potential of Adult Tissue-derived Stem Cells |
| Leonard Eisenberg, Ph.D. |
Regulation of Stem Cell Potential and Cardiac Induction |
| Robert
G. Gourdie, Ph.D. |
Developmental and Molecular Biology of Cardiac Conduction Wound Healing |
| Dhandapani
Kuppuswamy, Ph.D. |
Growth and Protection of Hypertrophing Myocardium |
| Amanda LaRue, Ph.D. |
Hematopoietic Stem Cells in the Development and Progression of Solid Tumors |
| Kyo
Ho Lee, M.D., Ph.D. |
Transcriptional Regulation in Cardiac Development |
| Roger
R. Markwald, Ph.D. |
Developmental Basis of Cardiovascular Disease |
| Paul
J. McDermott, Ph.D. |
Translational Regulation of Cardiac Protein Synthesis |
| Vladimir
Mironov, M.D., Ph.D. |
Cardiovascular Tissue Engineering and Cardiovascular Regenerative Medicine |
| Makio
Ogawa, M.D., Ph.D. |
Differentiation and Proliferation of Hemopoietic Stem Cells |
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| Francis
G. Spinale, M.D., Ph.D. |
Cellular Mechanisms of Heart Failure |
| Rick
Visconti, Ph.D. |
Role of Adult Bone Marrow Stem Cells in Cardiac Tissue Homeostasis and Injury-repair |
| Michael
R. Zile, M.D. |
Diastolic Heart Failure and Growth Regulation |
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©2003 MUSC |
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